Isaku Senagaki is the main protagonist of the manga & anime series: A Girl & Her Guard Dog. She is the granddaughter of a Yakuza Boss, who has an unrequited crush on Keiya Uto, where she is then enrolled in Otowa High School, unaware that Uto has lied about his age in order to join the same high school as her. Isaku is a very beautiful teenage girl who stands at average height with waist length platinum blonde hair, bangs that frame both sides of her face, a fair complexion, full pink lips, and soft purple eyes. When seen in school, she wears a white and navy colored seifuku with ankle length white socks and brown loafers. However, during casual outings or at home, she's seen to wear casual but feminine clothes. Isaku is noted to be a serious but timid girl. Because she's the granddaughter of a Yakuza boss, Isaku has never had the opportunity to make any friends throughout her childhood, and as a result of this - she doesn't do too well with social interactions. Hence her reclusive nature. Aside from her timid disposition, Isaku has shown determination to experience a "normal high school life" to its fullest potential by the time when she enrolled herself in the school she decided on her own.
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