Lilith

Lilith was known as a storm demon by the name of "Lilitu" in ancient Mesopotamian mythology, dating back to around 3000 BC. She was thought to be the creator of disease and death. Lilith is the leader of a quartet of entities called the Qadištu along with fellow demons Naamah, Eisheth Zenunim, and Agrat bat Mahlat. She appears with a new design in the remake. She stands in the way of the protagonist in order to accomplish a certain purpose.