Madame Boss

She is the founder of Team Rocket and passed her rank to her son, Giovanni. She controls armies, and gets Elite Squadrons to capture rare Pokémon and auction them off for money. She hates Pokémon, and that is why she has none. She only cares about the money she gets for selling them. The only Pokémon she truly wants, is Mew and Mewtwo. She thinks that with their power, she can rule the Pokémon world. That is why she gave a mission to her best woman, Miyamoto, to capture Mew and brainwash it. However, it would appear that Miyamoto ended up dying in an avalanche, while Madame Boss was succeeded by her son some years later.