Manuela is a playable character in Fire Emblem: Three Houses and Fire Emblem Warriors: Three Hopes. As an instructor at the Academy, she offers lessons in Swords and Faith. Manuela's love life is somewhat of a sore subject for her as she regrets not having met the man of her dreams at her age. She constantly makes flirtatious comments to potential suitors. She easily finds dates, but often is left unsatisfied or dumped after the first outings. She constantly worries that she will remain single for the rest of her life. She also loves her vices, mainly alcohol, as she drinks frequently and in vast quantities that often leave her in a drunken stupor the next day, which garnered her quite the reputation even back at Opera Company, leading to a joke that she "could outdrink a fish, and the sailor who caught it". She is sloppy and messy, her room often being a testament to her careless behavior. Despite the change of path, choosing a more stable career as a teacher in the monastery, Manuela has fond memories of her time as a songstress in the opera, regardless of all the hard work she had to do. She is also a skilled physician, being able to keep her spouse in good health for numerous years if she finally settles with someone, as seen in her paired ending with Edelgard. In addition, she has an interest in dressing fashionably and is good at needlework. Overall, Manuela is a friendly and supportive figure and cares for the well being of her students. Despite working in the monastery, she is not fond of the concept of status that supports nobility, treating all her colleagues and pupils equally. Her relationship with Hanneman is a shaky one, however, as their verbal spats often escalate into arguments over the slightest of infractions, which continues in their paired ending. Even so, they are able to maintain their professionalism in front of their students. She is also some sort of idol figure for Dorothea, who always sought to follow her steps and sees Manuela as a source of inspiration.